It occurs in 1–2% of asthma patients, although has been detected in up to 13% of the population in asthma clinics, predominately adults, and causes asthma exacerbations, deterioration of pulmonary function, mucous plugging, central bronchiectasis, and transient pulmonary infiltrates with characteristic biologic features including elevated total and Aspergillus-specific IgE as well as peripheral eosinophilia (88, 128, 129). Here, IGHE is linked to Increased total eosinophil count.