This is characterized by an stimulus at the level of the airway epithelium that results in production of IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) that stimulate release of IL-4, IL-5, and IL-13 and, in turn eosinophils and antibodies that lead to the pathogenic airway changes characteristic of asthma (90). The gene discussed is IL33; the disease is asthma.