Chukwuanukwu et al. recently showed that patients co-infected with malaria had an increase in the production of Th2-associated cytokine IL-4 and anti-inflammatory IL-10 in tuberculin-stimulated cells of TB patients >12 years of age compared to malaria-free TB patients, suggesting that malaria co-infection diverts immune response toward a Th2/anti-inflammatory response (231). This evidence concerns the gene IL4 and tuberculosis.