TNFRSF1A and esophageal cancer: CEH can regulate intestinal microenvironmental disorders caused by chemotherapy by adjusting the structure and function of intestinal microbes, activating TLR4-MYD88 innate immune signaling, activating the death receptor signaling interactive pathway, altering the esophageal cancer chemotherapeutic response, as well activating death receptors TNFR by the respective ligands to induce apoptosis.