In the literature the proteolytic cleavage of E-cad was reported for a number of sheddases, including zinc-dependent matrix metalloproteinases (MMP-2, -3, -7, -9 and -14), members of the disintegrin family (adamalysin/ADAM-10 and−15), bacterial proteases gingipains (HRgpA, RgpB, and Kgp), B. fragilis toxin/fragilysin, cysteine cathepsins (B, L, and S), serine protease Kallikrein-7 (KLK7), plasmin serine protease, aspartic proteinases BACE1 and BACE2, and malaria parasite serine proteinases PfSUB2n, PfROM1, and PfROM 4 (Grabowska and Day, 2012). The gene discussed is PLG; the disease is malaria.