IGHE and infection: For example, mast cells, leukocytes and eosinophils begin to increase immediately after infection (~2 DPI), peaked at 7–8 DPI and decreased in recovery phase (~12 DPI) (Silveira et al., 2002; Sasaki et al., 2005) whereas IgG and IgE levels peaked at 14 DPI (Matsumoto et al., 2013).