MAPK8 and hepatocellular carcinoma: In another experiment developed by Kim et al., the CAPE (30 μg/ml) potentiated TRAIL-induced apoptosis (30 ng/ml) through the positive regulation of DR5 via p38 (mitogen-activated protein kinases) and suppression of JNK (c-Jun N-terminal kinases) in SK-Hep1 cells of HCC (14, 63).