In our sample, IDH-wildtype patients showed lower FA, but higher MD, RD, and AD values of NAWM as compared to IDH-mutated glioma, which may indicate a less preserved microstructural integrity of NAWM than in IDH-mutated patients: With glioma cells invading the intercellular space along WM fibers (4), initial fiber displacement is ensued by axonal damage and disruption of the blood–brain barrier and leads to vasogenic edema. This evidence concerns the gene IDH1 and central nervous system cancer.