IDH2 and central nervous system cancer: In our sample, IDH-wildtype patients showed lower FA, but higher MD, RD, and AD values of NAWM as compared to IDH-mutated glioma, which may indicate a less preserved microstructural integrity of NAWM than in IDH-mutated patients: With glioma cells invading the intercellular space along WM fibers (4), initial fiber displacement is ensued by axonal damage and disruption of the blood–brain barrier and leads to vasogenic edema.