CCN4 and cancer: This results are perfectly in line with those already published from in vitro models: DKK1 and DKK3 have been shown to inhibit cancer cell proliferation (32) high levels of WNT6 inversely correlated with the response to chemotherapy in gastric cancer (33) WISP1 has been associated with a poor prognosis in glioblastoma (34, 35), and FZD8 up-regulation sustained resistance in breast cancer, prostate, and colorectal cancer (36–38).