Immune checkpoints are negative regulators of immune activation; exploiting the action of checkpoints such as cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death (PD-1), and its ligand programmed cell death ligand 1 (PDL-1) allows cancer cells to evade immune-surveillance, thus enabling unchecked tumor growth. This evidence concerns the gene CD274 and cancer.