Differently from CLL, in the other types of NHLs the immunophenotype is not really characteristic, and so flow cytometry is not widely employed for detecting MRD (66), except for HCL, where the combined expression of CD11c, CD103, CD123, and DBA44 allows to identify the neoplastic clone that can be then used during treatment and follow-up (67). This evidence concerns the gene ITGAX and B-cell chronic lymphocytic leukemia.