Thus, after the advent of Rituximab, the focus of the molecular studies assessing MRD in NHLs translated from the ASCT to the chemo-immunotherapy: in 2010, the European Organization for Research and Treatment of Cancer (EORTC) assessed MRD in 465 relapsed FL patients randomized to receive Cyclophosphamide, Doxorubicine, Vincristine, and Prednisone (CHOP) or R-CHOP (CHOP plus Rituximab) as induction and then Rituximab or not as maintenance. This evidence concerns the gene DDIT3 and cancer.