CD44 and cancer: Moreover, this DNA demethylation process regulated by HA-CD44-activated miR-302 can activate the expression of several Inhibitor of Apoptosis Protein (IAP) family of proteins such as c-IAP1, c-IAP2, and XIAP which appear to be closely linked to several important activities unique for cancer stem cells (CSCs) isolated from head and neck caner (31) (Figure 3B).