Downregulation of PI3K or AKT by treating cells with either PI3K inhibitor (GDC-0941) or AKT inhibitor (GSK795) effectively inhibits the complex formation between phospho-C/EBPa and the promoter region of lncRNA UCA1 in HA-treated CD44v3high head and neck cancer cells, as well as lncRNA UCA1 production (Figure 4B-2 and Figure 4C). The gene discussed is AKT1; the disease is head and neck cancer.