Since many LncRNAs have been shown to be closely associated with tumor cell-specific properties including cell survival, chemoresistance, tumor cell migration and invasion, it will also be possible to develop novel signaling perturbation techniques to simultaneously inhibit both oncogenic miRNAs and LncRNA UCA1 using miRNA-21/miRNA-10b/miR-302 RNAi inhibitor and/or lncRNA UCA1 RNAi inhibitor treatments. The gene discussed is UCA1; the disease is neoplasm.