The expression level of CNKSR2/KLF3/TNPO1 in October (HF flourishing period) are significantly higher than other months (p < 0.01) (Fig. 5A).The expression level of miR-21 in October are significantly decreases compared to other months (p < 0.01) (Fig. 5B). The gene discussed is CNKSR2; the disease is hydrops fetalis.