VIM and pulmonary fibrosis: Interestingly, it has been suggested that as fibrosis progresses and the lung stiffens, the increased mechanosensing by cells in the lung may lead to ongoing inflammasome activation as a way to perpetuate lung fibrosis.20 For example, vimentin has recently been identified as important for inflammasome activation and mice deficient in vimentin are protected from bleomycin‐induced fibrosis and do not stimulate IL‐1β production in response to bleomycin.21 This idea of mechanical feed forward innate immune activation is an interesting hypothesis about how fibrosis becomes progressive.