For example, aryl cyclopropyl sulfones have been used in the preparation of glucokinase (GK) activators for the treatment of type 2 diabetes [1–5] while aryl cyclopropyl sulfoximines have been utilized for the synthesis of modulators of glucokinase regulatory protein (GKRP) [6–8]. This evidence concerns the gene GCKR and type 2 diabetes mellitus.