MS4A2 and allergic disease: FCERI plays an essential role in IgE-mediated mechanisms and variants in FCERI genes have been previously described as genetic factors related to asthma (Cui et al., 2003; Kim et al., 2006; Palikhe et al., 2008; Joubert et al., 2011; Ramphul et al., 2014; Yang et al., 2014), allergy (Hasegawa et al., 2003; de Guia et al., 2015; Liao et al., 2015; Amo et al., 2016a,b), and food sensitization (Liu et al., 2011; Hong and Wang, 2012).