In the context of Chagas disease, several candidate antigens (e.g., ASP2, CRP, cruzipain, GP90, GP82, GP56, Tc24, Tc52) have been tested as subunit vaccine, delivered in the form of DNA, recombinant protein, or a host of viral and bacterial expression vectors, in small animal models [reviewed in Padilla et al. (19) and Zak and Aderem (20)]. This evidence concerns the gene CRP and Chagas disease.