Together, the results presented in Figure 3 suggest that (a) TcG2/TcG4 DNA vaccine induced DC depot was capable of responding to Tc infection by increased proliferation and phenotypic (antigen uptake, processing, and presentation to CD4+T cells) activation, and (b) fTr booster was not useful in enhancing the DC response induced by DNA vaccine in mice before or after challenge infection. This evidence concerns the gene CD4 and infection.