Challenge infection with T. cruzi led to > 3-fold increase in the frequency of CD11c+ DC and a comparable increase in the frequency of CD205+ and CD80+ DC in the splenic and LN compartment of mice that were immunized with TcG2/TcG4 DNA vaccine (compare Figures 3A,B with Figures 3C,D). The gene discussed is ITGAX; the disease is infection.