IFNAR1 and psoriasis: IMQ-induced psoriatic inflammation was blocked in Ifnar deficient (Ifnar−/−) mice, and in contrast IfnarSA mice (in which Ifnar ubiquitination and degradation was blocked) exhibited exacerbated inflammatory response to IMQ compared to wildtype controls (57), demonstrating that IFNAR plays a critical role in promoting the development of psoriasis like inflammation in mice.