After SVCV infection, the ectopic expression of nedd8 in zebrafish embryos via micro-injection of nedd8 mRNA upregulated the key antiviral genes, ifn1, mxc, pkz, and lta, as compared to the embryos injected with the control (GPF) mRNA (Figures 6A–D). The gene discussed is NEDD8; the disease is infection.