Interferon-regulatory factor (IRF) 3, IRF7 and Myxovirus resistance protein 1 (Mx1) genes are other representative ISGs that play key roles in IFN auto-regulation (such as IRF3 and IRF7 in further potentiation of IFN-β and IFN-α production in macrophages and pDCs, respectively) and in anti-Myxovirus (such as influenza) activity (10, 35, 36). Here, IRF3 is linked to influenza.