VEGF is considered the master regulator of angiogenesis and permeability, and is implicated as a driver of neovascularization and oedema in a number of diseases, hence anti-VEGF therapeutics are currently utilized in diseases ranging from age-related macular degeneration (AMD) to a number of forms of cancer (14, 15). The gene discussed is VEGFA; the disease is age-related macular degeneration.