Specifically, we observed in a preclinical mouse model of pemphigus that injections of immunodominant HLA-DRß1*04:02-binding T cell epitopes of Dsg3 conjugated either to antigen-presenting cells lacking a second co-stimulatory signal or to nanoparticles prevented the production of pathogenic anti-Dsg3 IgG. The gene discussed is DSG3; the disease is pemphigus.