Antibodies targeting the CTLA-4 and PD-1 pathways have shown the greatest clinical activity in tumor histologies with higher mutation load and brisk T-cell infiltrates such as metastatic melanoma, non-small-cell lung carcinoma (NSCLC), bladder cancer, and tumors with DNA-mismatch-repair deficiencies (12). This evidence concerns the gene CTLA4 and non-small cell lung carcinoma.