In this scenario, PMx and Soot induced recruitment of immunosuppressive DCs, macrophages and MDSCs was associated to the higher presence of Treg and higher levels of IL-10 (18), which render the lung less susceptible to acute inflammatory-driven damages, but pave the way for higher susceptibility to other respiratory disorders, such as fibrosis and, even worse, cancer (19). This evidence concerns the gene IL10 and cancer.