Although these results are obtained in mouse neuroblastoma cells, we recently reported that DENV2 infection in SH-SY5Y human neuroblastoma cells induces cell death, expression, and secretion of TNF-α as well as DNA fragmentation and Annexin V translocation, suggesting similar responses among species and validating these models (Castellanos J. E. et al., 2016). This evidence concerns the gene ANXA5 and neuroblastoma.