They revealed that GPS2, via interacting with different NRs (such as PPARα, LXR, FXR, LRH1, HNF4α, and SHP), plays important roles in metabolic and inflammatory regulation of liver pathways, some of which are involved in NAFLD/NASH (44, 86, 87). Here, GPS2 is linked to metabolic dysfunction-associated steatohepatitis.