In one large study, the mortality rate due to colon cancer was found to be increased in relation to high GH levels (14), but disease activity seemed not to play any major role in patients who had no colorectal lesions at their first colonoscopy (64) [although it is worth to note that in a recent case report a patient died from colon cancer with negative initial colonoscopy (12)]. This evidence concerns the gene GH1 and colonic neoplasm.