LZTFL1 and obesity disorder: Clinically, BBS patients are characterized with non-sense mutations of LZTFL1/BBS17 display obesity, polydactyly, diabetes, renal abnormalities, hypogenitalism, hypertension, cognitive impairment, and retinal degeneration (Schaefer et al., 2014; Novas et al., 2015; Khan et al., 2016).