AGER and obesity due to melanocortin 4 receptor deficiency: Recent studies have also shown that attenuation of RAGE signaling through an upregulation of sRAGE and esRAGE could be a veritable approach to treat obesity and prevent the development of its comorbidity (Yaw et al., 2013; Davis et al., 2014; Miranda et al., 2017, 2018; Susana et al., 2018).