AGER and obesity due to melanocortin 4 receptor deficiency: While this review underscores the need for the development of an esRAGE/sRAGE targeted pharmacotherapy as a treatment approach for obesity and its comorbidity, a key thing that must be taken into consideration is the duration and effect of RAGE sequestration or elimination in humans as RAGE has also been reported to play some beneficial roles in human physiology (Parisa and Ali, 2011; Yaw et al., 2013).