Gu et al. (2013) carried out a similar study to demonstrate the antiproliferation effects of BmK AGAP and realized that the analgesic–antitumor peptide BmK AGAP induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells by inactivating the PTEN/PI3K/Akt signaling pathway. Here, PTEN is linked to malignant colon neoplasm.