EPHX2 and neoplasm: This may be partly due to the specific fatty acids, which are epoxidized, as it appears that ω-3 epoxy fatty acid derivatives (e.g., epoxydocosapentaenoic acids) when stabilized by sEH inhibitors are anti-angiogenic and block tumor growth and metastasis, contrary to ω-6 ARA metabolites such as EETs (Zhang et al., 2013a).