AGTR1 and memory impairment: However, some important issues regarding the effects of AT1 receptor antagonists in stress-evoked depressive-like state and memory impairment are still to be addressed, including: i) comparison of the behavioral responses evoked by homotypic versus heterotypic stressors; ii) evaluation of depressive-like responses to stress in rats, including analysis of behaviors other than anhedonia and despair (e.g., self-care); iii) investigation of depressive-like effect evoked by homotypic stressors; and iv) evaluation of memory impairment evoked by heterotypic stressors.