Indeed, more evidence comparing species (e.g., rats vs mice), stress protocols (e.g., homotypic vs heterotypic), treatment time, and AT1 receptor antagonists (e.g., surmountable vs insurmountable antagonists) is necessary to provide more conclusive information regarding the efficacy of AT1 receptor antagonists in the treatment of stress-evoked depressive-like state and memory impairment. This evidence concerns the gene AGTR1 and memory impairment.