TGF-β1 plasma levels are reduced in MDD patients, correlate with depression severity, and significantly contribute to treatment resistance in MDD patients (Musil et al., 2011; Caraci et al., 2018), a clinical subgroup with an increased risk to develop AD (Chung et al., 2015; Li et al., 2017). This evidence concerns the gene TGFB1 and Alzheimer disease.