Although, the exact etiology of AD is still not known, several mechanistic features including the deficiency of cholinesterases, deposition of β-amyloid plaques, hyperphosphorylation of tau proteins and generation of oxidative stress have been implicated in the development as well as progression of AD (Kamal et al., 2015; Ullah et al., 2016). The gene discussed is MAPT; the disease is Alzheimer disease.