↑ Metal ions chelation ↑ Free radicals scavenging ↓Oxidative stress-induced DNA ↓ Fibril formation during Aβ aggregation ↓ ERK and NF-κB pathways ↓ Aβ induced lipid peroxidation ↓Aβ-induced apoptosis, Capse activity ↑ Neuronal survival ↑ Non-amyloidogenic APP ↓ Fibrillogenesis ↓ Formation of sarkosyl-soluble hosphorylated tau isoforms ↓Risk of Parkinson’s disease ↓ Neurodegeneration ↓Ischemic hippocampal injury ↑ Protein kinase C activity ↑ PI3-kinase activity ↑ Nigral damage via scavenging of free radicals ↑ Glutathione. This evidence concerns the gene MAPT and Parkinson disease.