Interestingly, IAPP has been discovered in AD brains, whereas Aβ and tau have been found in T2D pancreas; in addition, these proteins were seen to co-localize in brain and pancreas (Miklossy et al., 2010; Valente et al., 2010; Moreno-Gonzalez et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.