MAPT and Alzheimer disease: In fact, the use of statins, a cholesterol-lowering medication, such as simvastatin, has shown to lower the risk of AD diagnosis particularly in women (Zissimopoulos et al., 2017) even in ApoE homozygotes (Geifman et al., 2017) and levels of phospho-tau in the cerebrospinal fluid (CSF; Li G. et al., 2017).