Treadmill exercise also increases sirtuin-1 (SIRT-1), a modulator of neuronal survival, in a transgenic AD mouse (Koo et al., 2017) and enhances spatial memory in AD mice through upregulation of c-Fos, an indicator of neuronal activity expressed after depolarization (Jee et al., 2008). This evidence concerns the gene SIRT1 and Alzheimer disease.