As a label-free modality, it is applicable to most vertebrates, i.e., not limited to fluorescently-labeled transgenic mice, thus simplifying experimental designs for studying neurological disorders in models where OL markers, such as CNP and myelin-associated glycoprotein (MAG), are dysregulated (Davis and Haroutunian, 2003; Barley et al., 2009). This evidence concerns the gene CNP and nervous system disorder.