However, another study reported that Nrf2 activation was regulated by the TrkB-BDNF pathway (Bouvier et al., 2017) and the Nrf2 antioxidant axis was upregulated by BDNF overexpression in a rat model of traumatic brain injury (Chen et al., 2017; Ishii et al., 2018). This evidence concerns the gene BDNF and injury.