In vivo, using the hippocampal cognitive test just referenced, intravenous TOMA injection was shown to block the effect of intracerebroventricular (ICV) injection of AD brain-derived tau oligomers, an effect that was correlated with reduced levels of tau oligomers in the injected mouse brain (Castillo-Carranza et al., 2014). The gene discussed is MAPT; the disease is Alzheimer disease.