ATP13A2 and parkinsonism due to ATP13A2 deficiency: Although ATP13A2’s function in mammalian cells remains elusive, loss-of-function mutations in ATP13A2 cause Kufor-Rakeb Syndrome (KRS), an autosomal recessive form of early-onset Parkinsonism with pyramidal degeneration and dementia (Ramirez et al., 2006).