Indeed, several PD-linked gene mutations or polymorphisms (DNAJC13/RME-8, VPS35, ATP13A2, ATP6AP2, RAB7L1, GBA, GAK, LRRK2) interrupt protein trafficking and degradation via the endosomal pathway (Perrett et al., 2015), highlighting the importance of the endosomal pathway in the progression of neurodegenerative disease. This evidence concerns the gene VPS35 and Parkinson disease.