LRRK2 and Parkinson disease: Indeed, several PD-linked gene mutations or polymorphisms (DNAJC13/RME-8, VPS35, ATP13A2, ATP6AP2, RAB7L1, GBA, GAK, LRRK2) interrupt protein trafficking and degradation via the endosomal pathway (Perrett et al., 2015), highlighting the importance of the endosomal pathway in the progression of neurodegenerative disease.