In particular, neuronal hyperexcitability observed at early stages of both sporadic and familial AD and in AD mouse models was shown to increase tau release (Busche et al., 2008, 2012; Palop and Mucke, 2009; Bakker et al., 2012; Pooler et al., 2013; Wu et al., 2016). Here, MAPT is linked to Alzheimer disease.