SARM1 and amyotrophic lateral sclerosis: However, other approaches aimed at slowing Wallerian degeneration, such as the mutations in the Slowed Wallerian degeneration (WldS) and Sterile Alpha and TIR Motif Containing 1 (Sarm1) proteins, gave only modest or no results in terms of progression and survival (Fischer et al., 2005; Peters et al., 2018), suggesting that alternative mechanisms may underlie the axonal loss observed in ALS.