Finally, pleckstrin homology and RhoGEF domain containing G5 (PLEKHG5) and mitofusin 2 (MFN2) genes, whose mutations are known to cause CMT (Muglia et al., 2001; Zuchner et al., 2004a, 2006; Engelfried et al., 2006; Del Bo et al., 2008; Nicholson et al., 2008; Azzedine et al., 2013; Kim et al., 2013; Iapadre et al., 2018), have been also reported in patients with ALS or an “ALS-like” phenotype (Marchesi et al., 2011; Ozoguz et al., 2015). This evidence concerns the gene PLEK and amyotrophic lateral sclerosis.