Notably, an agonist antibody directed toward muscle-specific kinase (MuSK), a post-synaptic tyrosine kinase receptor essential for NMJ maintenance, preserved motor synapses, delayed muscle denervation and extended lifespan in hSOD-1G93A ALS mice (Cantor et al., 2018). This evidence concerns the gene NTRK1 and amyotrophic lateral sclerosis.