The multivariate Cox regression analysis revealed that TIMP-2 or MMP-9 expression was an independent and unfavorable prognostic factor for CRC patients (TIMP-2: HR, 0.372, 95% CI, 0.250–0.554, P < 0.001; MMP-9: HR, 0.346, 95% CI 0.249–0.480, P < 0.001; Table 4). This evidence concerns the gene MMP9 and colorectal carcinoma.