Kaplan-Meier survival analysis was conducted by 5-year overall cumulative survival, which revealed that low TIMP-2 or high MMP-9 expression in cancer tissues was correlated with a worse OS in CRC patients (P < 0.001 and P < 0.001, respectively, log-rank test; Figure 2c and 2d). The gene discussed is MMP9; the disease is colorectal carcinoma.