Impaired adipocyte differentiation was also evident in pluripotent stem cells (iPSCs) derived from Hutchinson-Gilford Progeria Syndrome (HGPS) cells by Xiong et al. [18] and in 3T3-L1 cells stably expressing LMNA R482Q or R482W [19], supporting a critical role for LMNA in adipocyte differentiation [20]. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.