Mutations in LMNA trigger changes in nuclear architecture, signal transduction, and gene regulation, associated with a group of multisystem diseases termed laminopathies; these are characterized by lipodystrophy, muscular dystrophy, neuropathies, premature ageing syndromes, diabetes associated with insulin resistance, and (rarely) overlapping syndromes [1]. This evidence concerns the gene LMNA and laminopathy.