Although classified as likely pathogenic according to ACMG criteria the relevance of the patient`s MYBPC3‐missense variant p.Gly148Arg (c.442G>A) for the SCD‐event is hard to predict since it was previously shown to be associated with incomplete penetrance and variable expressivity within a family (Hoedemaekers et al., 2010). The gene discussed is MYBPC3; the disease is Schnyder corneal dystrophy.