In this study, therefore, a possible involvement of TRPM7 in acidotoxic NVI and necrotic death in human cervical cancer HeLa cells was first investigated, not only because the normal vaginal pH is strongly acidic but also because TRPM7 is known to be aberrantly expressed in malignant tumor cells (Yee, 2017). This evidence concerns the gene TRPM7 and cervical carcinoma.