To combat the harm caused by oxidative stress, cells defend themselves with enzymes such as SOD, catalase and glutathione peroxidase.26 There is overwhelming evidence indicating that increased oxidative stress and reduced activity of antioxidants are closely related to the development and propagation of cardiac hypertrophy and HF in animal models and humans.5, 6 Nrf2 is a redox‐sensitive transcription factor that normally resides in the cytoplasm bound to keap1. The gene discussed is KEAP1; the disease is cardiac hypertrophy.