Poor prognosis is associated with age at diagnosis older than 18 months, metastases or undifferentiated histopathology, and amplification of the oncogene MYCN. Although disseminated neuroblastomas in infants undergo spontaneous regression, a high proportion of older patients with metastatic neuroblastomas succumb to disease despite the multimodal treatment currently considered standard of care (Maris, 2010). The gene discussed is MYCN; the disease is neuroblastoma.