We found that the expression of three splicing factor genes, HNRNPM, HNRNPA0 and AKAP17A may be predictive for change in in this population; all three genes were associated with cognitive decline as measured by the Mini-Mental State Examination (MMSE), Trail-Making Tests part A and B (TMT A/B), and the Purdue Pegboard Test (PPT). This evidence concerns the gene HNRNPA0 and Mental deterioration.