Functional experiments knocking down Tm6sf2 in mice [25] as well as TM6SF2 in human hepatoma cell lines [26] both supported that reduced gene expression increased liver triglyceride content and decreased secretion of triglyceride-rich lipoproteins from liver tissue, thus implicating TM6SF2 in liver fat metabolism. The gene discussed is TM6SF2; the disease is hepatocellular carcinoma.