Subsequently, exome chip analysis containing protein-coding variants across the genome identified an amino acid–altering variant in TM6SF2 p.Glu167Lys as significantly associated with T2D, and two variants resulting in amino acid substitutions in this gene (p.Glu167Lys and p.Leu156Pro) were driving the locus association signal [15••]. Here, TM6SF2 is linked to type 2 diabetes mellitus.