In epithelial cells, only SH2B3 was differentially methylated between CeD patients and controls (p = 0.003), whereas in the lamina propria, the genes IL21 (p = 0.03), TNFAIP3 (p < 0.001) and cREL(p = 0.005) showed differences in methylation level between CeD and CTRs. Here, IL21 is linked to cranioectodermal dysplasia.