To name a few of those detected exclusively in SALS patients (i.e., absent from controls) are ALDH4A1, a component of the mitochondrial matrix contributing to protect cells from oxidative stress42; BIN1, the most significant late-onset susceptibility locus for Alzheimer’s disease whose alterations in expression levels and splicing seem to induce muscle weakness and T tubule alterations43, and RABGAP1L, a GTPase-activating protein whose loss-of-function exacerbates neuronal loss44. The gene discussed is RABGAP1L; the disease is Alzheimer disease.