These included some genes (SYNE1, SDK1, EEF1D, GSDMD, TIMP2, CST3, ALAD, AKT1, EPHA4, SPAST, SMN1, SETX, ATXN2, TBK1, SPG11, TAF15, MMP9) previously reported as potential risk factors in ALS, as well as novel candidates whose association with ALS was previously unappreciated. This evidence concerns the gene CST3 and amyotrophic lateral sclerosis.