Another interesting association is represented by a 162.362-kb duplicated region in 1p36.12 spanning several neuronal genes, including the FBXO42 encoding an important member of the F-box protein family involved in the ubiquitin-proteasome system and already known to be associated with ALS (Table 2)37. This evidence concerns the gene FBXO42 and amyotrophic lateral sclerosis.